Molecular Locks

Configurations

Molecular Locks are molecular assemblies engineered to bind cooperatively, specifically and tightly to structural phrases within a target nucleic acid. Molecular Locks can be made to selectively bind to specific nucleic acid targets within genomes, including the nucleic acids of viruses, bacteria, plants, animals and engineered chromosomes. Molecular Locks can be configured for nucleic acid detection, genetic engineering, or disease gene target regulation.

LockBox Configuration
In the LockBox configuration, the target nucleic acid is engaged by a target binding assembly (TBA) that brackets and protects the nucleic acid, forming a “handle” on the nucleic acid. One or more handles can be used to engage a molecule that acts as a molecular barcode. A handle can also be used to immobilize a target nucleic acid.

Spooling Configuration
The spooling of a target nucleic acid by a target binding assembly (TBA) shuts off associated genes. Molecular Locks are engineered to bind to and wrap up specific sequences in the target genome and, like histones, may provide for the sustained suppression of undesirable gene products in vivo.

Hairpin Configuration
Hairpinning of a target nucleic acid is a way of turning on genes regulated by that target nucleic acid.